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Thursday, June 2, 2011

Kawasaki's disease

~ Also called Kawasaki's syndrome,described as a " vasculitic syndrome"  - disease of the blood vessels
~ Disease of childhood.
~ First described by a Japanese doctor named Tomisaku Kawasaki in 1967.
~ Common in infants aged from 6-12 months.
~ Also occur in children older than 5 years.
~ Most common in boys rather than girls.
~ Researchers suspect something infectious such as viruses or bacterias.
~ It trigger off immune reactivity and the child's own " altered " immune system than turn against his own body to his blood vessels.
~ Having a prolonged fever 39 degrees celsius and unresponsive to antibiotic.
~ Changes in the hands and feet such as swelling,redness or rash and peeling of skin ( desquamation )
~ Not wish to move the hands and feet much,find it difficult to walk. ( happens in 75 % of all cases,2 weeks after the fever's onset )
~ Conjuctivitis of both eyes ( 85% of cases )
~ A rash occurs throughout the body ( 80% of cases ) some occurs in the groin or legs .
~ Enlarged neck lymph nodes.
~ Changes in the lips like swelling,redness or dryness and fissuring.
~ Have a strawberry tongue-(red and the papillae stands clearly out )
~ Fever and rash phase last for 1-2 weeks during this time,heart muscle and the layer surrounding it may be inflamed.
~ After the fever comes another phase until week four,- no appetite,continue to have conjuctivitis,skin changes in the hand and feet are noted.
~ Internal blood vessels(especially the coronary arteries) develop aneurysms-weakening of the vessel walls leading to a bulge.This phase is at the highest risk of death.
~ After the second phase comes the recovery phase the aneurysms are still present the child may have to live with aneurysms for the rest of the life.
~ Aneurysms may come back to haunt him when they rupture during adulthood.
~ The treatment is actually to decrease the severity of the immune reaction.
~ 2% die due to heart attack or heart complications.

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